Preliminary experience with rifampicin and isoprodian (L73A)--combination in lepromatous leprosy.
نویسندگان
چکیده
Out of 1 3 patients under treatment, 1 0 patients so far have beco me b acteriologically nega tive, accompanied by clinicai improvement, especially in the macular, nodular and diffuse types of infiltration, whereas m iliary and lenticular types of infiltration improved slightly. Side-effects were mild, except in I patient who dropped out because of severe vomiting. Laboratory examinations showed no significant' changes"iri the blood picture and the initial high value of ESR gradually decreased .
منابع مشابه
Preliminary report of a drug trial conducted at Leprosy Relief Rural Centre, Chettipatty, South India.
The drug combination (rifampicin + Isoprodian) therapy continues for 7 cases, it has been stopped for 1 9 cases-out of which 1 0 cases receive dapsone treatment ranging from 2 5 to 400 mgf week , the other 9 cases are without DDS subj ected to further observation and follow-u p . Ali, b u t 2 cases could again resume work which for s o m e of t h e m h a d n o t been possible for years gone by....
متن کاملRifampicin for lepromatous leprosy: nine years' experience.
Over 100 patients with lepromatous leprosy were treated with rifampicin in a series of pilot, uncontrolled, and controlled trials in 1968-77. The rapid bactericidal effect of rifampicin on Mycobacterium leprae was confirmed. Clinical improvement became apparent sometimes as early as 14 days after the start of treatment. Nevertheless, a few persisting viable M leprae were detected as long as fiv...
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Following a rewarding initial experience in the treatment of leprosy and tuberculosis with the combination of rifampicin and Isoprodian and taking into account the excellent results of the Malta-Project, the Paraguayan Government, through its Ministry of Health, resolved to initiate an eradication programme of both these diseases which constitute important public health problems in the country ...
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The Malta Leprosy Eradication Project (MLEP) was proposed in 1971 by Freerksen with the aim of eradicating leprosy in Malta. The project involved re-treatment of all known cases in Malta as of 1972 and all new cases thereafter with a regimen consisting of Isoprodian (a combination of dapsone, prothionamide and isoniazid) and rifampicin for varying intervals depending on the severity of their di...
متن کاملRifampicin-resistant Mycobacterium leprae in an elderly leprosy patient in the people’s Republic of China
The reported number of registered leprosy patients worldwide declined with the introduction of multidrug therapy. However, the emergence of rifampicin resistance in leprosy patients engenders difficulties for an individual patient, and its dissemination could pose a threat to leprosy control. This study reports an elderly patient who was diagnosed with rifampicin-resistant lepromatous leprosy. ...
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عنوان ژورنال:
- Leprosy review
دوره 46 2 Suppl شماره
صفحات -
تاریخ انتشار 1975